Fig. 4.

Changes in serum creatinine (SC) levels in animals treated with warfarin and vitamin K. Warfarin (0.75 mg/kg/24 h) results in increased sINR above 4 within 1 week. Co-treatment with warfarin and vitamin K (vit K) (40 mg/kg/24 h) prevented sINR increase (A). SC was increased in 5/6 nephrectomy rats treated with warfarin only, but not with warfarin and vitamin K together (B). A Control and 5/6 nephrectomy animals 3 weeks (5/6NE 3W) and 9 weeks (5/6NE 9W) after the ablative surgery were treated with warfarin per os (0.75 mg/kg) and either vehicle (+ vehicle) or vitamin K (intraperitoneally 40 mg/kg/24 h, + vit K). Animals received warfarin and vehicle had progressive increase in PT (shown as sINR), whereas co-treatment with vitamin K prevented sINR increase. Changes in SC levels in control (B), 5/6 nephrectomy rats 3 weeks after the ablative surgery (5/6NE 3W; C), 5/6 nephrectomy rats 9 weeks after the ablative surgery (5/6NE 9W; D) treated with warfarin (0.75 mg/kg/24 h) and either vehicle (n = 6 in each group) or vitamin K (40 mg/kg/24 h) (n = 6 in each group). * p < 0.05 compared to vehicle-treated animals. Serum creatinine was measured before the surgery and weekly thereafter until treatment with warfarin and vitamin K began.