Fig. 5.

Changes in serum creatinine (SC) levels in 5/6 nephrectomy rats after a single episode of warfarin-related nephropathy. A 5/6 nephrectomy rats 8 weeks after the ablative surgery were treated with warfarin (0.75 mg/kg/24 h) for 8 days. This resulted in a rapid prothrombin time (PT) (shown as sINR) increase of more that 4-fold. Treatment with warfarin was stopped and vitamin K (40 mg/kg) was administered. This resulted in a rapid PT decline. B, C SC was increased with PT increase in 5/6 nephrectomy rats treated with warfarin 8 weeks after the ablative surgery (solid circles, n = 6; B) or 3 weeks after the ablative surgery (solid circles, n = 6; C). The time of the treatment with warfarin is scaled differently; the duration of warfarin treatment is shown as a solid line. After the warfarin treatment cessation and PT normalization, SC levels returned to the levels comparable with 5/6 nephrectomy rats treated with vehicle (no warfarin) 3 and 8 weeks after the ablative surgery (solid squares, n = 9). SC levels were monitored daily in both experimental groups until 22 weeks after the ablative surgery.