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. 2012 Oct 12;109(41):674–679. doi: 10.3238/arztebl.2012.0674
Medication Response Ε
+
A (raltegravir) 293 (84.4%) 54 (15.6%) 347 (100.0%)
B (lopinavir + ritonavir) 319 (90.6%) 33 (9.4%) 352 (100.0%)
Ε 612 87 699

Setting the non-inferiority margin at 0.5 and using SASTM software (for details see [4, section 6.6.1]), the p value Psε for this contingency table comes out as 35.04%, far above the usual significance level of 5%. Thus, non-inferiority of raltegravir to the combination therapy with regard to the odds ratio cannot be confirmed on the basis of these data.