Figure 2.

Systolic PAP (sPAP) before and after surgical closure of ASD in 65 patients with PH. Most patients had considerable reduction in PAP after repair, indicating that a large component of the pre-operative PH was not due to PVO. (Note that this figure overestimates the fall in PVR with ASD closure since most patients had increased PBF prior to operation.) Systolic PAP was used as mean PAP and PVR was not available in all studies. Data are from seven studies and include only patients with systolic PAP > 50 mmHg. Patients were all adults except in Cohn[163] and Walker,[164] which included an indeterminate number of children. Time from surgery to the post-operative cath was 2 months to 10 years, except in one patient (2 weeks). Data do not reflect intra- and postoperative deaths, and underestimates the incidence of progressive PH since in some patients PAP increases with time after ASD closure.[158,163,165–168]