Figure 3.

Cumulative percent reduction in odds of death at 24 months with each sequentially applied guideline-recommended HF therapy. Therapies were sequenced on the basis of their β-coefficients and the order in which they are commonly applied clinically. Variables retained in the model were race, HF etiology, and diastolic blood pressure. Incremental P values for the sequentially applied therapies (left to right) were as follows: <0.0001, <0.0001, <0.0001, 0.0038, 0.1388, and 0.1208, respectively. ACEI indicates angiotensin-converting enzyme inhibitor; AF, atrial fibrillation; ARB, angiotensin receptor blocker; CRT, cardiac resynchronization therapy (with defibrillator or pacemaker); HF, heart failure; ICD, implantable cardioverter-defibrillator (including CRT with defibrillator).