Table 2.
Clinical Characteristics and Biological Parameters of Patients with coronary artery disease (CAD) and Matched Controls
| Controls | CSA | AMI | P-Value | |
|---|---|---|---|---|
| No. | 40 | 30 | 60 | |
| Age(y) | 61 (±9) | 64 (±11) | 64 (±11) | 0.37 |
| Male Sex—no. (%) | 32 (80) | 22 (73) | 46 (77) | 0.81 |
| Family history of CAD | 17 (43) | 12 (40) | 20 (33) | 0.95 |
| Current smoker | 14 (35) | 7 (23) | 25 (42) | 0.23 |
| Hypertension | 20 (50) | 22 (73) | 36 (60) | 0.14 |
| Diabetes mellitus | 0 (0) | 3 (10) | 5 (8) | 0.14 |
| Hypercholesterolemia | 22 (55) | 19 (63) | 29 (48) | 0.40 |
| Troponin I (ng/mL) | – | – | 0.4 (0.1–1.1) | – |
| WBC (109/L) | 6.5±1.4 | 7.9±1.4 | 11.1±4.0* | <0.0001 |
| Lymphocytes (109/L) | 2.2±0.5 | 2.2±0.4 | 2.4±0.6 | 0.11 |
| Monovessel disease | – | 11 (37) | 22 (37) | 0.42 |
| Bivessel disease | – | 7 (23) | 21 (35) | |
| Trivessel disease | – | 12 (40) | 17 (28) | |
| Aspirin | 2 (5) | 22 (73)* | 36 (60)* | <0.0001 |
| Thienopyridine | 0 (0) | 8 (27)† | 14 (23)† | 0.003 |
| β-blockers | 1 (3) | 14 (47)* | 16 (40)* | <0.0001 |
| Statins | 1 (3) | 14 (47)* | 10 (17)† | <0.0001 |
| Ca-blockers | 4 (10) | 8 (27) | 5 (8) | 0.04 |
| ACE inhibitors/ARBs | 9 (23) | 12 (40) | 23 (38) | 0.19 |
| Nitrates | 0 (0) | 11 (37)* | 24 (40)* | <0.0001 |
| Diuretics | 5 (13) | 4 (13) | 6 (10) | 0.87 |
*
<0.001 vs controls after Bonferroni post hoc test.
†
<0.01 vs controls after Bonferroni post hoc test.
ACE indicates angiotensin converting enzyme; ARBs, angiotensin receptor blockers; CAD, coronary artery disease; WBC, whole blood count.