Table 3.
Description of All T-Cells Subpopulation Analyzed
| CD3+CD4+T Subsets | Subpopulations | Levels (% of CD3+CD4+) |
|---|---|---|
| Naïve CD45RA+RO−CCR7+ | ||
| CXCR3+ | 1.1 (1.1) | |
| CCR5+ | 0.9 (0.8) | |
| HLA-DR+ | 0.2 (0.2) | |
| CXCR3+CCR5+ | >0.1* | |
| CXCR3+CCR5− | 0.1 (0.1) | |
| CXCR3−CCR5+ | >0.1* | |
| CXCR3+HLA-DR+ | >0.1* | |
| CXCR3+HLA-DR− | 1.0 (1.0) | |
| CXCR3−HLA-DR+ | >0.1* | |
| CD45RA+RO−CCR7−† | 2.4 (1.7) | |
| CXCR3+ | 0.1 (0.1) | |
| Central memory T CD45RA−RO+CCR7+ | ||
| CXCR3+ | 20.1 (7.3) | |
| CCR5+ | 5.2 (3.6) | |
| HLA-DR+ | 3.8 (1.9) | |
| CXCR3+CCR5+ | 3.1 (2.4) | |
| CXCR3+CCR5− | 17.1 (6.1) | |
| CXCR3−CCR5+ | 2.2 (1.7) | |
| CXCR3+HLA-DR+ | 1.8 (1.1) | |
| CXCR3+HLA-DR− | 18.4 (6.9) | |
| CXCR3−HLA-DR+ | 2.0 (1.2) | |
| Effector memory T CD45RA−RO+CCR7− | ||
| CXCR3+ | 5.2 (2.5) | |
| CCR5+ | 0.8 (0.5) | |
| HLA-DR+ | 1.0 (0.7) | |
| CXCR3+CCR5+ | 2.0 (1.9) | |
| CXCR3+CCR5− | 3.9 (2.1) | |
| CXCR3−CCR5+ | 0.6 (0.5) | |
| CXCR3+HLA-DR+ | 0.4 (0.3) | |
| CXCR3+HLA-DR− | 4.2 (2.3) | |
| CXCR3−HLA-DR+ | 0.6 (0.4) | |
| CD45RA+RO+‡ | 5.6 (3.5-8.5) | |
| CD45RA+RO+CCR7+ | 5.2 (3.1-7.8) | |
| CXCR3+ | 1.1 (0.8-1.5) | |
| CCR5+ | 0.5 (0.3-0.7) | |
| HLA-DR+ | 0.1 (0.1) | |
| CXCR3+CCR5+ | 0.4 (0.2–0.5) | |
| CXCR3+CCR5− | 0.7 (0.5–1.1) | |
| CXCR3−CCR5+ | 0.1 (0.04–0.2) | |
| CXCR3+HLA-DR+ | >0.1* | |
| CXCR3+HLA-DR− | 1.0 (0.7–1.4) | |
| CXCR3+HLA-DR+ | >0.1* | |
| CD45RA+RO+CCR7− | 0.4 (0.2–0.7) | |
| CXCR3+ | 0.1 (0.04–0.13) | |
| CCR5+ | >0.1* | |
| HLA-DR+ | >0.1* | |
| CXCR3+CCR5+ | >0.1* | |
| CXCR3+CCR5− | 0.1 (0.03–0.11) | |
| CXCR3−CCR5+ | >0.1* | |
| CXCR3+HLA-DR+ | >0.1* | |
| CXCR3+HLA-DR− | 0.1 (0.04–0.11) | |
| CXCR3+HLA-DR+ | >0.1* | |
Data are presented as mean±standard deviation or median (25th quartile to 75th quartile) as appropriate.
*
We did not report precise values in case of small subpopulations with frequencies below 0.1% as median or mean value.
†
CD45RA+RO−CCR7− is a naive subpopulation that had lost the expression of CCR7. This subpopulation is small and non–well characterized.
‡
CD45RA+RO+ represents a subpopulation of transition from a naïve to memory phenotype that coexpresses both CD45RA and CD45RO.