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. 2012 Feb 20;1(1):8–15. doi: 10.1161/JAHA.111.000059

Table 1.

Eligible Studies Sorted by Publication Date

Acronyms Trial Publication
UKPDS33 UK Prospective Diabetes Study 8 Lancet. 1998;352:837–853.

IDNT Irbesartan in Patients with Nephropathy due to Type 2 Diabetes 9 N Engl J Med. 2001;345:851–860.

RENAAL Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan 10 N Engl J Med. 2001;345:861-869.

DIABHYCAR Non–insulin-dependent DIABetes, Hypertension, microalbuminuria or proteinuria, CARdiovascular events, and Ramipril 11 BMJ. 2004;328:495–500.

DAVID Atherosclerotic Vascular Disease in Diabetics 12 Eur Heart J. 2004; 25:1845–1852.

CARDS Collaborative Atorvastatin Diabetes Study 13 Lancet. 2004;364:685–696.

BENEDICT Bergamo Nephrologic Diabetes Complications Trial 14 N Engl J Med. 2004;351:1941-1951.

COSMIC Comparative Outcomes Study of Metformin Intervention versus Conventional 15 Diabetes Care. 2005;28:539–543.

PROactive PROspective pioglitAzone Clinical Trial In macroVascular Events 16 Lancet. 2005;366:1279–1289.

FIELD Fenofibrate Intervention and Event Lowering in Diabetes 17 Lancet. 2005;366:1849–1861.

ASPEN The Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in Non-Insulin-Dependent Diabetes Mellitus 18 Diabetes Care. 2006;29:1478–1485.

ADOPT A Diabetes Outcome Progression Trial 19 N Engl J Med. 2006;355:2427–2443.

ACCORD Action to Control Cardiovascular Risk in Diabetes 20 N Engl J Med. 2008;358:2545–2559.

ADVANCE Action in Diabetes and Vascular Disease 21 N Engl J Med. 2008;358:2560-2572.

DIRECT-2 DIabetic REtinopathy Candesartan Trial 22 Lancet. 2008;372:1385–1393.

JPAD Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes 23 JAMA. 2008;300:2134–2141.

VADT Veterans Affairs Diabetes Trial 24 N Engl J Med. 2009;360:129–139.

DIAD Detection of Ischemia in Asymptomatic Diabetics 25 JAMA. 2009;301:1547–1555.

RECORD Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycemia in Diabetes 26 Lancet. 2009;373:2125–2135.

BARI2D Bypass Angioplasty Revascularization Investigation 2 Diabetes 27 N Engl J Med. 2009;360:2503–2515.

TREAT Trial to Reduce Cardiovascular Events With Aranesp Therapy 28 N Engl J Med. 2009;361:2019–2032.

ROADMAP The Randomized Olmesartan and Diabetes Microalbuminuria Prevention 29 N Engl J Med. 2011;364:907–917.