Table 1.
Baseline Characteristics and Plasma SSH Levels Among Cases of Ischemic Arterial Disease and Noncase Subjects in the 3C Case–Cohort Study
| Ischemic Arterial | |||
|---|---|---|---|
| Noncases | Disease Cases* | ||
| Characteristic | (n=522) | (n=106) | P† |
| Age, y, mean±SD | 74.3±5.3 | 76.6±5.7 | <0.01 |
| Study center, n (%) | 0.38 | ||
| Bordeaux | 120 (23.0) | 31 (29.3) | |
| Dijon | 269 (51.5) | 51 (48.1) | |
| Montpellier | 133 (25.5) | 24 (22.6) | |
| Education level, n (%) | 0.55 | ||
| Less than grade school | 206 (39.5) | 42 (39.6) | |
| Grade school or high school | 154 (29.5) | 36 (34.0) | |
| High school validated or university | 162 (31.0) | 28 (26.4) | |
| BMI‡, kg/m2, mean±SD | 25.6±4.8 | 26.5±4.7 | 0.10 |
| Glycemia§, n (%) | <0.01 | ||
| Normal glycemia | 466 (89.5) | 80 (75.5) | |
| High glycemia | 20 (3.8) | 4 (3.8) | |
| Diabetes | 35 (6.7) | 22 (20.7) | |
| Hypertension, n (%) | 398 (76.3) | 92 (86.8) | 0.02 |
| Hypercholesterolemia, n (%) | 330 (63.2) | 70 (66.0) | 0.58 |
| Smoking, n (%) | 0.83 | ||
| Never | 427 (81.8) | 86 (81.1) | |
| Past | 70 (13.4) | 16 (15.1) | |
| Current | 25 (4.8) | 4 (3.8) | |
| Age at menopause‖, y, mean±SD | 49.4±5.6 | 48.6±6.1 | 0.17 |
| Type of menopause#, n (%) | 0.74 | ||
| Natural | 421 (81.4) | 84 (79.2) | |
| Bilateral oophorectomy | 41 (7.9) | 8 (7.6) | |
| Other | 55 (10.7) | 14 (13.2) | |
| SSHs, geometric mean (interquartile range) | |||
| Total estradiol, pg/mL | 5.19 (3.47–7.91) | 6.05 (4.42–9.22) | <0.01 |
| Bioavailable estradiol, pg/mL | 3.48 (2.28–5.63) | 4.04 (2.69–6.40) | <0.01 |
| Total testosterone, ng/mL | 0.29 (0.21–0.45) | 0.28 (0.20–0.44) | 0.49 |
*
Including 67 CHD and 39 stroke events.
†
P value obtained from Student t tests or χ2 tests except for SSHs, where Cox model was used.
‡
Two missed values
§
1 missed value
‖
6 missed values
#
5 missed values.