Figure 7.
Cellular ROS production during hypoxia/reoxygenation. A, Representative fluorescence images of cardiac ventricular myocytes loaded with the ROS sensor CM-DCF. ROS bursts during reoxygenation preceded cell death, and Bendavia treatment prevented ROS-induced cell death. B, Representative fluorescence intensity traces for cells in the study. CM-DCF fluorescence is normalized to the basal fluorescence (Fo) for each cell at the end of hypoxia. C, Contribution of ROS bursts to myocyte death during hypoxia/reoxygenation.