Effect of hRenalase1 on BP in rat models of chronic kidney disease (5/6 Nx). BP was recorded for 2 days before and after treatment. Each data point represents the average of systolic (blue) or diastolic (red) BP values collected every 5 min for 6 h in 4 animals. The standard errors of the means are shown. A, Buffer control in 5/6 Nx rats. Arrow indicates buffer administration. Friedman test revealed no statistical significance. B, Single subcutaneous injection of recombinant renalase in 5/6 Nx rats. Arrow indicates renalase administration. Friedman test revealed statistical significance; Dunn's test was used for pairwise comparisons; *P<0.05. C, Enalapril (5 mg/kg) provided in drinking water for 24 hours to 5/6 Nx rats. Arrow indicates enalapril administration. Friedman test revealed statistical significance; Dunn's test was used for pairwise comparisons; *P<0.05.