Table 6.
Comparison of Anterior and Nonanterior Infarctions: Estimated Effects on CMR Parameters Associated With a 20% Increase in IMR (mm Hg/s)
| Anterior STEMI (n=47) | Nonanterior STEMI (n=61) | |||
|---|---|---|---|---|
| IMR Effect (95% CI) | P | IMR Effect (95% CI) | P | |
| Multivariable associations,* early CMR (2 days) | ||||
| Infarct size, % | 2.11 (0.89 to 3.32) | 0.001 | 1.38 (0.64 to 2.12) | <0.001 |
| Myocardial salvage index, % | −3.97 (−6.16 to −1.78) | <0.001 | −3.28 (−5.12 to −1.43) | <0.001 |
| Microvascular obstruction, % | 0.37 (0.10 to 0.64) | 0.009 | 0.14 (−0.09 to 0.38) | 0.225 |
| Hemorrhage, % | 0.26 (0.08 to 0.44) | 0.006 | 0.18 (0.03 to 0.32) | 0.019 |
| Left ventricular ejection fraction, % | −0.76 (−1.77 to 0.26) | 0.145 | −0.62 (−1.10 to −0.13) | 0.016 |
| Multivariable associations,† late CMR (3 months) | ||||
| Infarct size, % | −0.08 (−0.77 to 0.61) | 0.812 | 0.04 (−0.41 to 0.48) | 0.894 |
| Myocardial salvage index, % | −1.07 (−2.95 to 0.81) | 0.266 | 0.10 (−1.32 to 1.52) | 0.892 |
| Left ventricular ejection fraction, % | −0.89 (−1.53 to −0.26) | 0.008 | 0.02 (−0.40 to 0.44) | 0.921 |
Results are additive effects on the CMR parameters.
*
For all baseline CMR outcomes, adjustment was made for the following variables: previous MI, sex, pain‐to‐balloon time, door‐to‐balloon time, thrombectomy, catheterization laboratory pulse pressure, TIMI flow, corrected TIMI frame count, and percent of ST elevation still present after PCI.
†
For all follow‐up CMR outcomes, we adjusted for baseline value of the CMR parameter, age, door‐to‐balloon time, glycoprotein IIb/IIIa, TIMI flow, and percent of ST elevation still present after PCI.