Skip to main content
. 2012 Aug 24;1(4):e000091. doi: 10.1161/JAHA.111.000091

Figure 5.

Figure 5.

Proposed pathway for activation of NADPH oxidase, generation of superoxide, and upregulation of the endothelin system in the peripheral circulation after OSA and chronic intermittent hypoxia (black lines). An alternative pathway that could be responsible for generation of superoxide in the cerebral circulation (red lines).112 Dashed red lines (and “?”), which lack any experimental evidence, represent hypothetical pathways. HIF indicates hypoxia inducible factor.