Figure 2.

Diazoxide, a mitochondrial adenosine triphosphate-sensitive potassium channel opener, eliminates human myocyte swelling secondary to hypothermic hyperkalemic cardioplegia. After a 20 minutes period of exposure to control 37°C Tyrode's physiological solution (Tyr 37°C), isolated myocytes were exposed to test solution for 20 minutes (n=12 in each), and then reexposure to Tyr 37°C for 20 minutes. Cell volume change is represented as percent change from baseline (y axis) vs time (x axis). (*P<0.05 vs Tyr 37°C, +P<0.05 vs St. T 9°C).