Table 2.
Incidence Rate Ratios (IRR) and 95% confidence intervals of CHD According to Quintiles of Total HDL-C, HDL-C Without ApoC-III and HDL-C With ApoC-III in the Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS)
| Q1 | Q2 | Q3 | Q4 | Q5 | P trend | |
|---|---|---|---|---|---|---|
| Total HDL-C | ||||||
| NHS (median, range) | 1.17 (0.32–1.37) | 1.53 (1.38–1.67) | 1.81 (1.68–1.97) | 2.12 (1.98–2.36) | 2.68 (2.37–4.20) | |
| Unadjusted | 1.0 (ref) | 0.86 (0.51–1.45) | 0.67 (0.37–1.21) | 0.70 (0.39–1.26) | 0.32 (0.15–0.65) | 0.003 |
| Multivariate | 1.0 (ref) | 0.88 (0.50–1.54) | 0.68 (0.36–1.30) | 0.79 (0.41–1.51) | 0.41 (0.18–0.92) | 0.05 |
| HPFS (median, range) | 0.81 (0.22–0.93) | 1.04 (0.93–1.14) | 1.23 (1.14–1.33) | 1.42 (1.33–1.58) | 1.79 (1.58–3.59) | |
| Unadjusted | 1.0 (ref) | 0.58 (0.36–0.94) | 0.64 (0.38–1.07) | 0.48 (0.27–0.84) | 0.46 (0.25–0.85) | 0.02 |
| Multivariate | 1.0 (ref) | 0.59 (0.36–0.97) | 0.68 (0.40–1.16) | 0.54 (0.30–0.96) | 0.53 (0.28–1.01) | 0.07 |
| HDL-C without ApoC-III | ||||||
| NHS (median, range) | 0.95 (0.03–1.14) | 1.32 (1.14–1.46) | 1.59 (1.46–1.75) | 1.88 (1.75–2.11) | 2.39 (2.12–3.70) | |
| Unadjusted | 1.0 (ref) | 0.90 (0.49–1.65) | 0.57 (0.29–1.11) | 0.58 (0.28–1.22) | 0.20 (0.09–0.49) | 0.0001 |
| Multivariate | 1.0 (ref) | 1.03 (0.54–1.95) | 0.68 (0.33–1.42) | 0.74 (0.33–1.65) | 0.30 (0.12–0.77) | 0.006 |
| HPFS (median, range) | 0.71 (0.19–0.83) | 0.90 (0.83–1.00) | 1.09 (1.00–1.18) | 1.27 (1.18–1.42) | 1.61 (1.42–3.34) | |
| Unadjusted | 1.0 (ref) | 0.39 (0.23–0.68) | 0.52 (0.30–0.93) | 0.32 (0.17–0.59) | 0.26 (0.13–0.53) | 0.006 |
| Multivariate | 1.0 (ref) | 0.38 (0.21–0.67) | 0.61 (0.34–1.09) | 0.35 (0.19–0.66) | 0.32 (0.16–0.66) | 0.03 |
| HDL-C with apoC-III | ||||||
| NHS (median, range) | 0.12 (0.01–0.16) | 0.16 (0.15–0.20) | 0.23 (0.20–0.26) | 0.28 (0.26–0.32) | 0.39 (0.33–0.59) | |
| Unadjusted | 1.0 (ref) | 0.86 (0.47–1.56) | 1.12 (0.62–2.04) | 1.09 (0.57–2.09) | 1.58 (0.79–3.16) | 0.08 |
| Multivariate | 1.0 (ref) | 0.78 (0.41–1.46) | 1.12 (0.60–2.11) | 1.00 (0.51–1.99) | 1.44 (0.69–3.01) | 0.14 |
| HPFS (median, range) | 0.07 (0.01–0.08) | 0.10 (0.09–0.11) | 0.13 (0.12–0.14) | 0.16 (0.14–0.18) | 0.22 (0.18–0.51) | |
| Unadjusted | 1.0 (ref) | 1.15 (0.69–1.93) | 1.34 (0.80–2.32) | 1.19 (0.66–2.15) | 1.77 (0.96–3.24) | 0.07 |
| Multivariate | 1.0 (ref) | 1.10 (0.64–1.89) | 1.32 (0.74–2.33) | 1.19 (0.65–2.19) | 1.76 (0.94–3.31) | 0.08 |
Incidence rate ratios (IRR) obtained from conditional logistic regression models. Unadjusted model takes into account age and smoking (due to matching). Multivariate model includes: alcohol, body mass index, self-reported diagnosis of hypertension before blood draw, and postmenopausal status and hormones in NHS only. HDL with and without apoC-III are simultaneously included in all models. P trend is the test for linear trend across quintiles.