Table 3.

Incidence Rate Ratios (IRR) and 95% confidence intervals of CHD According to Continuous Measures of Total HDL-C (per 0.60 mmol/L), HDL-C Without ApoC-III (per 0.53 mmol/L), and HDL-C with ApoC-III (per 0.07 mmol/L) in the Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS)

	NHS		HPFS			Together
	Per SD	P	Per SD	P	P het	Per SD	P
Total HDL-C
Unadjusted	0.69 (0.54–0.87)	0.002	0.70 (0.52–0.95)	0.02	0.9	0.69 (0.58–0.83)	0.0001
Adjusted	0.77 (0.59–1.01)	0.06	0.79 (0.57–1.10)	0.2	0.9	0.78 (0.63–0.96)	0.02
+ triglycerides and apoB	0.81 (0.61–1.07)	0.14	0.85 (0.61–1.18)	0.3	0.8	0.83 (0.68–1.01)	0.06
+ diabetes	0.80 (0.60–1.05)	0.11	0.86 (0.61–1.20)	0.4	0.7	0.82 (0.66–1.02)	0.07
HDL without ApoC-III
Unadjusted	0.55 (0.42–0.73)	0.0001	0.61 (0.44–0.85)	0.003	0.6	0.58 (0.47–0.71)	<0.0001
Adjusted	0.64 (0.47–0.87)	0.004	0.70 (0.50–0.97)	0.03	0.7	0.66 (0.53–0.83)	0.0001
+ triglycerides and apoB	0.70 (0.50–0.98)	0.04	0.85 (0.60–1.21)	0.4	0.4	0.77 (0.60–0.98)	0.03
+ diabetes	0.73 (0.82–1.02)	0.07	0.87 (0.61–1.25)	0.4	0.5	0.79 (0.62–1.01)	0.06
HDL with ApoC-III
Unadjusted	1.16 (1.00–1.35)	0.05	1.20 (0.97–1.47)	0.09	0.8	1.17 (1.04–1.32)	0.01
Adjusted	1.16 (0.99–1.35)	0.07	1.21 (0.98–1.51)	0.08	0.7	1.18 (1.03–1.34)	0.01
+ triglycerides and apoB	1.10 (0.93–1.30)	0.3	1.00 (0.78–1.29)	0.9	0.6	1.07 (0.93–1.23)	0.4
+ diabetes	1.04 (0.87–1.24)	0.6	0.97 (0.76–1.25)	0.8	0.7	1.02 (0.88–1.18)	0.8

Incidence rate ratios (IRR) obtained from conditional logistic regression models.Unadjusted model takes into account age and smoking (due to matching). Multivariate model includes: alcohol, body mass index, self-reported diagnosis of hypertension before blood draw, and postmenopausal status and hormones in NHS only. HDL with and without apoC-III are simultaneously included in all models. The NHS and HPFS data were combined using random effects meta-analyses. P het=P for test of between study heterogeneity