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. 2012 Apr 24;1(2):e000570. doi: 10.1161/JAHA.112.000570

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© 2012 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell.

This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 3. — Sex- and mutation-location–specific QT-RR dynamic profiles in LQT-1 patients. We plotted the QT-RR profiles for men and women across all groups and circadian periods. Curves modeling the QT-interval duration for the controls (black dots), CL QT-1 (white dots), and NCL LQT-1 (squares) groups for the diurnal (lines) and nocturnal (dotted lines) periods are displayed. On average, the CL LQT-1 men have most abnormal QTc prolongation for elevated heart rate (above 70 bpm, RR≤857ms), while the range of heart rate with abnormal QT-interval duration is larger (above 60 bpm, RR≤1000 ms). We superimposed the curve describing QTc=500 ms, and grayed the areas corresponding to the range of RR and QT values associated with higher risk for cardiac events.