Table 3.
Sex-Specific QT-RR Dynamic Profile by Mutation Location in Controls and LQT-1 Patients
| Controls | CL LQT-1 | NCL LQT-1 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Male (n=98) | Female (n=97) | P | Male (n=7) | Female (n=11) | P | Male (n=19) | Female (n=29) | P | |
| Diurnal | |||||||||
| RR, ms | 753±93* | 728±105* | 0.08 | 842±162 | 759±100 | 0.24 | 765±80 | 743±79 | 0.19 |
| QTc, ms | 427±20* | 439±21 | <0.001 | 481±25 | 503±26 | 0.08 | 481±29 | 492±21 | 0.09 |
| QT/RR slope | 0.105±0.048* | 0.132±0.053* | <0.001 | 0.070±0.055 | 0.124±0.037 | 0.05 | 0.137±0.075 | 0.175±0.080 | 0.05 |
| Nocturnal | |||||||||
| RR, ms | 941±142 | 895±137 | 0.02 | 1003±180 | 852±111* | 0.08 | 911±137 | 965±142 | 0.30 |
| QTc, ms | 417±24 | 436±23 | <0.001 | 480±24 | 484±23 | 0.21 | 479±30 | 484±25 | 0.08 |
| QT/RR slope | 0.08±0.045 | 0.119±0.054 | <0.001 | 0.119±0.059 | 0.133±0.058 | 0.37 | 0.136±0.070 | 0.153±0.093 | 0.81 |
*
Significance (P≤0.05) when compared to NCL LQT-1 group for same sex; P: P values when comparing means between genders.