Table 3.
In Vivo UBM-Derived Newborn Hemodynamic Measurements
| Newborn | ||
|---|---|---|
| Functional Parameter | Wildtype | TAZKD |
| N | 16 | 9 |
| Weight, g | 1.15±0.05 | 1.01±0.04* |
| Heart rate, beats/min | 260±13 | 244±3 |
| PR interval, ms | 76±3 | 82±3 |
| Isovolumic contraction time, ms | 24±5 | 31±11 |
| Isovolumic relaxation time, ms | 47±1 | 50±6 |
| Diastolic septal thickness, mm | 0.27±0.01 | 0.27±0.01 |
| Diastolic LV dimension, mm | 1.34±0.03 | 1.31±0.04 |
| Diastolic LV posterior wall, mm | 0.26±0.01 | 0.26±0.01 |
| Systolic septal thickness, mm | 0.39±0.01 | 0.39±0.01 |
| Systolic LV dimension, mm | 0.92±0.03 | 0.93±0.03 |
| Systolic LV posterior wall, mm | 0.40±0.03 | 0.35±0.01* |
| LV shortening fraction,% | 31±2 | 29±1 |
| LV end-diastolic area, mm2 | 1.413±0.070 | 1.375±0.058 |
| LV fractional area change,% | 50.8±1.4 | 49.4±1.1 |
Data are expressed as means±SEM.
LV indicated left ventricular; TAZKD, tafazzin knockdown.
NB: Because of technical challenges, only a limited subset of data could be obtained on newborn pups. It should be noted that newborn pups are not anesthetized during imaging. There were no significant differences between wildtype and TAZKD newborn echo functional parameters; although systolic LV posterior wall achieved statistical significance (*P<0.05), the large number of comparisons in this table and the absence of other differences in cardiac morphometry and function cast doubt as to the relevance of this finding.
*
Weight was significantly lower in the TAZKD newborn pups (P<0.05).