Table 1.
Parameter estimates for intracellular-signaling tumor-regression model
| Parameter symbol (Units) | Definition | Population mean (%RSE) | IIV standard deviation as CV % (%RSE) |
|---|---|---|---|
| kinUp,Dlmn (USU/(ng/ml)/day) | Production constant of dulanermin Upstream Signal | 0.0944 (8.96) | 36.2 (18.6) |
| koutUp, Dlmn (1/day) | Turnover rate constant of dulanermin Upstream Signal | 8.45 (6.73) | 30.7 (19.8) |
| kinUp,Cmab (USU/(ng/ml)/day) | Production constant of conatumumab Upstream Signal | 0.00543 (4.86) | 45.8 (9.82) |
| koutUp,Cmab (1/day) | Turnover rate constant of conatumumab Upstream Signal | 11.9 (9.38) | 34.8 (20.9) |
| kinApop,UpSig (ASU/USU/day) | Production constant of Apoptosis Signal due to Upstream Signal | 0.0253 (11.1) | 34.1 (28.4) |
| koutApop (1/day) | Turnover rate constant of Apoptosis Signal | 1.62 (8.63) | 38.9 (17.5) |
| kDeath (1/ASU/day) | Rate constant for tumor cell loss due to Apoptosis Signal | 0.514 (11.3) | 32.9 (32.2) |
| kG (1/day) | Tumor net growth rate constant | 0.124 (3.14) | 47.2 (5.80) |
| TVSS (mm3) | Steady-state (maximum) tumor volume | 4890 (10.9) | 28.0 (28.4) |
| TV(0) (mm3) | Initial tumor volume | 275 (2.59) | 36.0 (3.74) |
| Proportional Error Variance | 0.326 | ||
| NLL | 23492 | ||
| AIC | 47115 |
% RSE Relative standard error of estimate presented as a percentage, ASU Apoptosis Signal unit, USU Upstream Signal unit, CV% coefficient of variation, IIV inter-individual variability, NLL negative log likelihood, AIC Akaike’s information criterion