Table 1.

Demographic, Clinical, and Caudolateral Orbitofrontal Counts/Voxel in Control and Cocaine-addicted Cohorts^a

	Cohort 1				Cohort 2
Demographic Characteristics	Control (n = 35)	Cocaine-Addicted (n = 33)	t, x2 or F value	P-value	Control (n = 20)	Cocaine-Addicted (n = 26)	t, x2 or F value	P-value
Age	33.0 ± 6.7	38.3 ± 5.2	3.6b	0.001	34.3 ± 7.1	38.2 ± 6.6	1.9b	0.06
Gender	16 male	23 male	2b	0.05	10 male	16 male	0.8b	0.44
Race, n (%)			24.4c	0.001			6.1c	0.05
Black	6	25			9	20
White	20	7			9	6
Hispanic	6	1			2	0
Asian	3	0			0	0
Cigarette packs/years	0.14 ± 0.35	12.6 ± 17.6	3.8b	0.001	0.24 ± 0.72	14.6 ± 13.7	4.4b	0.001
Cocaine use in days, 90 days prior to treatment		53 ± 30				70 ± 25
Cocaine use in $, 90 days prior to treatment		1750 ± 1597				1754 ± 1198
Cocaine use in days, lifetime		227361 ± 403888				259997 ± 298266
Cocaine use in $, lifetime		1750 ± 1597				1859 ± 1269
Left OFC counts/voxele	75.0 ± 4.1	71.4 ± 5.4	6.42d	0.02	72.9 ± 3.6	69.0 ± 4.8	7.16d	0.02
Right OFC counts/voxele	73.4 ± 4.0	70.8 ± 4.8	4.58d	0.04	72.1 ± 4.8	69.3 ± 4.4	1.63d	0.21

^avalues reported as mean ± SD

^bvalues obtained by t-test

^cvalues obtained by x²-test

^dvalues obtained by univariate analysis of variance

^erelative rCBF determined as counts/voxel normalized to whole brain counts in anatomically defined caudolateral OFC, adjusted for age, race, and gender