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Determination of peptide solubility in high acetonitrile solutions. (a) Number of proteins and peptides identified in the insoluble portion of a dried yeast lysate digest exposed to various concentrations of acetonitrile, analyzed by RPLC-MS. (b) Number of proteins and peptides identified in the soluble portion of a dried yeast lysate digest exposed to various concentrations of acetonitrile, analyzed by RPLC-MS.
