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. 2012 Nov;97(11):1699–1703. doi: 10.3324/haematol.2012.067306

Figure 2.

Figure 2

At diagnosis patients with Schnitzler syndrome had increased circulating levels of VEGF (A) and angiogenin (B) compared to healthy controls and decreased angiopoietin-1 (C) and angiopoietin-1/angiopoietin-2 ratio (D) suggesting increased angiogenic activity. After successful treatment with pefloxacin or anakinra, VEGF levels decreased (387±207 pg/mL) compared to baseline values (P=0.04). (E) Three patients who progressed to overt WM had decreased levels of angiopoietin-1 to angiopoietin-2 ratio at diagnosis compared to all other patients (5.3±4.6 vs. 16.5±8.0; P=0.04, F).