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. Author manuscript; available in PMC: 2013 Oct 16.
Published in final edited form as: Cancer Cell. 2012 Oct 16;22(4):438–451. doi: 10.1016/j.ccr.2012.09.015

Figure 3. Cyclin D3 Is Required for Maintenance of Notch1-ICD-driven T-ALL In Vivo.

Figure 3

(A) Schematic representation of the experimental design. After T-ALL formation in the recipient mice, cyclin D3 ablation was induced at six and a half weeks post BMT.

(B) Representative FACS analysis showing percentage of Notch1-ICD-overexpressing GFP+ cells in spleens right after completion of pI-pC administration (started 6.5 weeks post BMT) in cyclin D3F/F/Mx1-Cre+ (D3Δ/Δ) or D3F/F/Mx1-Cre− (D3F/F) mice. SSC, side scatter.

(C) Mean percentages of GFP+ cells in spleens in mice treated as in (B). Error bars, SD, n=4.

(D) Kaplan-Meier analysis of survival time in each group, n=6. See also Figure S3.