ECM molecule transcript levels as detected by real-time RT-PCR in VIP- versus PBS-treated B6 corneas after ocular infection. ITG-α1 (A) levels were significantly elevated with VIP treatment at 1, 3, and 5 days PI, while CD44 (B), LAMA-1 (C), ECM-1 (E), and VCAN (F) levels were significantly enhanced 3 and 5 days PI when compared to PBS controls. VIP treatment significantly reduced SPP-1 (F) at 1, 3, and 5 days PI.
* ITG-α1: P = 0.04 (day 1), < 0.001 (day 3), = 0.003 (day 5); CD44: P = 0.040 (day 3) and 0.004 (day 5); LAMA-1: P < 0.001 (day 3) and = 0.022 (day 5); ECM1: P < 0.001 (N, day 1, day 3, day 5); VCAN: P < 0.001 (N, day 3, day 5); SPP1: P < 0.001 (day 1, day 3, day 5).