Fig. 5.
GnrhrE90K prevents ovulation and luteinization. A and B, Ovaries from both wild-type (A) and E90K/+ (B) mice exhibited normal histology, including multiple corpora lutea (asterisks) and follicles in all stages of growth. C, In contrast, almost all ovaries from E90K homozygotes displayed multiple antral follicles and no corpora lutea. D, No follicular development past the primary stage was observed for L117P homozygotes. On the left are stereomicroscope images. Scale bar, 1 mm. On the right are hematoxylin- and eosin-stained sections. Scale bar, 0.2 mm. E, The total number of corpora lutea on both ovaries was counted. The data are plotted as the mean number of corpora lutea present on both ovaries. Error bars represent sem.