Fig. 4.

Intersection of ERα and AR sites in ZR-75–1 cells with published cistrome data. A, Euler diagrams showing the number of chromosomal locations shared between AR-binding sites in ZR-75–1 cells and those published in prostate cancer LNCaP and breast cancer apocrine MDA-MB-453 cells (10, 41) and between the ERα-binding sites in ZR-75–1 cells and those published in breast cancer MCF-7 cells (32). B, Relationship between increasing peak stringency in the ZR-75–1 cistromes and intersection with published data; “base” refers to all peaks identified in ZR-75–1 cells with the percentage overlap corresponding to data in panel A, and x-axis numbers represent increments of increased stringency of ZR-75–1 AR or ERα peaks from that base. C, Overlap of AR- and ERα-binding sites with published FOXA1 sites in ZR-75–1 cells (43). Shown are the proportion of all AR and ERα peaks (base), as well as two increments of increased peak stringency as per panel B that intersect directly or within a 5-kb window of FOXA1 sites.