Fig. 1.

A, Multiple sequence alignment of the inner faces of the LRR of RXFP1 and RXFP2 from human (H. sapiens), orangutan (P. abelii), dog (C. familiaris), horse (E. caballus), rat (R. norvegicus), mouse (M. musculus), and opossum (M. domestica) and compared with the human Nogo receptor (NgR), which was used for the homology models. Residues involved with INSL3 binding to RXFP2 and conserved in RXFP1 are indicated (*), whereas RXFP2-specific residues that were investigated experimentally are labeled with φ. B, Homology model of the LRR of RXFP2 with receptor-specific residues identified in the multiple sequence alignment highlighted as previously described (7).