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Proposed hypothetical model for the function of DMP1 and PHEX interaction in the regulation of FGF23 and bone mineralization in the context of nonmutant WT (A), mutant Phex (B), mutant Phex overexpressing the full-length Dmp1 transgene (C), and mutant Phex overexpressing the C-terminal Dmp1 transgene (D).
