Table 1.

Serum and urine biochemistry of WT, Dmp1^ko, Dmp1^ko/Dmp1^{Tg(full length)}, and Dmp1^ko/Dmp1^{Tg(57 kDa)}

	WT	Dmp1ko	Dmp1ko/Dmp1Tg(full length)	Dmp1ko/Dmp1Tg(57 kDa)
Serum
Full-length FGF23 (pg/ml)	94.1 ± 8.1	1402.5 ± 121.0a	181.1 ± 32.7a, b	139.5 ± 45.9b
1,25(OH)2D (pg/ml)	168.6 ± 19.2	198.2 ± 37.4	132.3 ± 10.2	200.2 ± 35.9
PTH (pg/ml)	44.6 ± 7.9	92.4 ± 17.6a	82.4 ± 40.3	70.8 ± 23.0
Pi (mg/dl)	8.2 ± 0.4	4.2 ± 0.2a	6.4 ± 1.4b	7.6 ± 0.6b
Ca (mg/dl)	7.8 ± 0.3	6.6 ± 0.1a	7.2 ± 0.5	6.9 ± 0.1a, b
Urine
FE phosphate (%)	18.9 ± 3.1	26.7 ± 5.7	11.6 ± 0.2	11.8 ± 1.2b
FE calcium (%)	0.8 ± 0.1	1.1 ± 0.3	1.4 ± 0.5	0.4 ± 0.1a

Values are expressed as mean ± se from at least five mice per group at 5 wk of age. Comparisons were performed using one-way ANOVA and post hoc Fisher test. FE, Fractional excretion.

^aP < 0.05 vs. WT.

^bP < 0.05 vs.Dmp1^ko.