. 2012 Aug 28;26(11):1883–1895. doi: 10.1210/me.2012-1062

Table 3.

3D-μCT analysis of femur distal metaphysis trabecular structure and midshaft cortical envelope

	WT	Dmp1^{Tg (full length)}	Dmp1^{Tg (57 kDa)}	Hyp	Hyp/Dmp1^{Tg (full length)}	Hyp/Dmp1^{Tg (57 kDa)}
Trabecular bone parameters
Tb.BMD (mg HA/cm³)	149.9 ± 11.3	121.1 ± 25.0	122.5 ± 19.6	2.1 ± 0.8^a	1.2 ± 0.6^a	2.8 ± 1.2^a
BV/TV (%)	21.2 ± 1.2	18.6 ± 3.4	18.7 ± 3.1	0.7 ± 0.1^a	0.5 ± 0.2^a	0.4 ± 0.1^{a, b}
Tb.N. (⁻¹)	5.2 ± 0.2	5.1 ± 0.3	4.8 ± 0.2	1.8 ± 0.1^a	1.7 ± 0.1^a	1.7 ± 0.1^a
Tb.Th (μm)	56.9 ± 3.1	46.4 ± 2.7^a	44.9 ± 4.0^a	34.8 ± 1.8^a	35.5 ± 3.2^a	33.8 ± 1.2^a
Tb.Sp (μm)	188.6 ± 8.4	209.6 ± 17.1	208.2 ± 12.0	575.1 ± 23.7^a	640.5 ± 39.1^a	610.4 ± 33.7^a
Conn.Dens.	231.8 ± 17.8	253.3 ± 19.3	200.4 ± 15.5	1.8 ± 0.7^a	1.4 ± 1.2^a	1.0 ± 0.9^a
SMI	1.7 ± 0.1	2.1 ± 0.2^a	1.9 ± 0.3	3.6 ± 0.1^a	3.8 ± 0.2^a	3.7 ± 0.2^a
DA	1.89 ± 0.05	1.84 ± 0.02	1.76 ± 0.02	1.70 ± 0.03^a	1.66 ± 0.07^a	1.65 ± 0.08^a
Cortical bone parameters
Ct.BMD (mg HA/cm³)	862.0 ± 8.3	819.9 ± 15.0^a	844.4 ± 11.6	572.4 ± 16.5^a	580.9 ± 15.8^a	509.7 ± 18.3^{a, b}
Ct.Th. (μm)	146.2 ± 7.3	130.1 ± 4.8	141.7 ± 8.6	54.8 ± 3.2^a	55.7 ± 2.8^a	44.0 ± 2.7^{a, b}
CSA (mm²)	2.31 ± 0.09	2.45 ± 0.10	2.37 ± 0.05	2.76 ± 0.10^a	2.49 ± 0.10^b	2.42 ± 0.05^b
Ct.Ar. (mm²)	0.60 ± 0.03	0.58 ± 0.04	0.57 ± 0.03	0.20 ± 0.02^a	0.20 ± 0.02^a	0.14 ± 0.02^{a, b}
Ma.Ar. (mm²)	1.73 ± 0.06	1.81 ± 0.08	1.81 ± 0.05	2.58 ± 0.08^a	2.44 ± 0.06^a	2.26 ± 0.04^{a, b}

Values are expressed as mean ± se from eight mice per group at 5 wk of age. Comparisons were performed using one-way ANOVA and post hoc Fisher test. Tb.BMD, Trabecular bone mineral density; Conn.Dens, connectivity density; DA, degree of anisotropy; Ct.BMD, cortical bone mineral density; Ct.Th, cortical thickness; CSA, cross sectional area; Ct.Ar, cortical area; Ma.Ar, marrow area.

P < 0.05 vs. WT.

P < 0.05 vs.Hyp.