Table 4.
Serum and urine biochemistry of WT, Dmp1Tg(full length), Dmp1Tg(57 kDa), Phex-deficient (Hyp), Hyp/Dmp1Tg(full length), and Hyp/Dmp1Tg(57 kDa) mice
| WT | Dmp1Tg (full length) | Dmp1Tg (57 kDa) | Hyp | Hyp/Dmp1Tg (full length) | Hyp/Dmp1Tg (57 kDa) | |
|---|---|---|---|---|---|---|
| Serum | ||||||
| Full-length FGF23 (pg/ml) | 94.1 ± 8.1 | 105.9 ± 14.2 | 88.2 ± 11.1 | 1149.8 ± 310.6a | 1330.0 ± 351.3a | 2269.8 ± 373.1a,b |
| Degraded C-terminal FGF23 (pg/ml) | 52.9 ± 6.1 | 61.2 ± 9.2 | 54.0 ± 7.6 | 427.8 ± 6.3a | 373.6 ± 14.9a,b | 232.0 ± 52.4a,b |
| 1,25(OH)2D (pg/ml) | 168.6 ± 19.2 | 142.8 ± 33.1 | 236.1 ± 18.0a | 183.1 ± 22.7 | 198.4 ± 35.5 | 290.2 ± 35.1a,b,c |
| PTH (pg/ml) | 44.6 ± 7.9 | 35.2 ± 10.1 | 28.9 ± 5.0a | 75.4 ± 15.7a | 86.6 ± 18.9a | 87.2 ± 20.9a |
| Pi (mg/dl) | 8.2 ± 0.4 | 9.7 ± 0.5a | 9.0 ± 0.3 | 4.6 ± 0.3a | 5.3 ± 0.5a | 4.5 ± 0.4a |
| Ca (mg/dl) | 7.8 ± 0.3 | 6.8 ± 0.1a | 7.8 ± 0.2 | 7.5 ± 0.3 | 6.9 ± 0.1a | 6.4 ± 0.1a,b,c |
| Urine | ||||||
| FE phosphate (%) | 18.9 ± 3.1 | 11.1 ± 1.8a | 13.6 ± 1.9 | 6.2 ± 1.8a | 24.9 ± 4.7b | 21.2 ± 2.4b |
| FE calcium (%) | 0.8 ± 0.1 | 0.7 ± 0.1 | 0.8 ± 0.2 | 0.3 ± 0.1a | 0.8 ± 0.3 | 0.9 ± 0.2b |
Values are expressed as mean ± se from at least five mice per group at 5 wk of age. Comparisons were performed using one-way ANOVA and post hoc Fisher test. FE, Fractional excretion.
a
P < 0.05 vs. WT.
b
P < 0.05 vs. Hyp.
c
P < 0.05 vs. Hyp/Dmp1Tg(full-length).