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. 2012 Mar;102(3):541–556. doi: 10.2105/AJPH.2011.300401

TABLE 3—

Study Outcomes in Literature Review on Association Between Returning to Work and Health Among Working-Aged Adults

Study Sample Size at Each Data Collection Point, No. (% completed) Follow-up (Data Collection Points, No.). Health Outcomes (Confounders) Main Findings
Beiser et al.79,a Baseline: 1348Follow-up: 1169 (87) 2 y (2) Depressive affect (Baseline depression score, education, gender, age, baseline and follow-up marital status) With all other factors controlled, the consistently employed had significantly lower depression scores at follow-up than the consistently unemployed or people who lost their jobs between baseline and follow-up, but not lower than the previously unemployed who found jobs by follow-up
Starting a job between baseline and follow-up was accompanied by lowered depression scores
Refugees employed at baseline who went on to lose their job had higher initial depression levels than the initially employed who kept on working
Bond et al.80,a Baseline: 149Follow-up 1: 149 (100)Final follow-up: 149 (100) 1.5 y (4) Psychiatric symptoms [BPRS score total] (Group assignment [IPS versus control], months of paid employment in past 5 y, Global Assessment Scale days in hospital in past year) Clients with severe mental illness who worked in competitive employment for an extended period showed a greater rate of improvement in several nonvocational outcomes (including overall BPRS); statistical differences partially attributable to deterioration in minimal work and nonworking groups
Competitive group unchanged on the BPRS total from baseline to 18 mo; nonworking group deteriorated substantially
Breslin and Mustard20,b Baseline: 6096Final follow-up: 6096 (100) 2 y (2) Distress, depression (Gender, marital status, education, unusual life events, chronic medical condition) Adults aged 31–55 y who became unemployed more likely to report elevated distress at follow-up 1 than those who remained employed; review analyses of cases of clinical depression showed similar but somewhat weaker association (causation for job loss, not return-to-work effect)
High distress increased risk of not finding work; review analysis found that unemployment predicted distress and distress predicted employment status, supporting selection hypothesis
Review analyses did not show increased distress at follow-up among those unemployed at both time points, suggesting adaptation to unemployment
Bromberger and Matthews81,a Baseline: 541Final follow-up: 524 (97) 3 y (2) Depression [BDI] (Education, marital status) Depressive symptoms decreased among newly employed and increased for others
New employment appeared to have acute positive effect on mood
Caplan et al.82,a Baseline: 928Follow-up 1: 693 (75)Final follow-up: 628 (68) 4 mo (3) Depression, anxiety, quality of life (Baseline scores for dependent variables) People who found reemployment scored significantly lower on anxiety, depression, and anger and higher on self-esteem and quality of life than persons who remained unemployed
Claussen83,84,ac Baseline: 310Follow-up 1: 291 (94)Final follow-up: 210 (68) 2 y835 y84 (3) Somatic symptoms, anxiety, depression, psychiatric syndrome personality disorder, hormones [cortisol, testosterone, prolactine], immunoglobins (Education, years in paid work, duration of longest-lasting job, gender, socioeconomic status, social network, health measures at baseline) At 5-y follow-up, considerable recovery after reemployment, supporting causation hypothesis84Results differed from 2-y follow-up, when selection was remarkable and recovery after reemployment was fairly small83Psychiatric syndrome diagnosis at baseline (1988) reduced odds of having job in 1993; 43% of changes occurred in participants without a diagnosis
Claussen85,ad Baseline: 310Follow-up 1: 291 (93.9)Final follow-up: 228 (73.5) 5 y (3) Alcohol dependency (Gender, age, education, socioeconomic status, social network, employment, commitment, AUDIT case for alcohol dependency at baseline) Obtaining job significantly reduced chances of scoring positive on AUDIT questionnaire from 1988 to 1993 to 34% of odds for still-unemployed persons; calculating continuous AUDIT scores in linear regression with continuous covariates gave same result (P = .02); recovery likely same as deterioration after job loss
Selection mechanism probably not major cause of high prevalence of alcohol problems in unemployed populations
DiClementi et al.86,b Unemployed–employed:baseline: 135Final follow-up: 135 (100)Unemployed–unemployed:Baseline: 135Final follow-up: 135 (100) 5 y (2) Mental illness [other than substance abuse, psychiatric diagnoses, injection drug use] Return-to-work group had significantly more psychiatric diagnoses other than substance abuse than matched control group; control group had significantly more diagnoses related to injection and other drug use, possibly because accessing mental health services was entry point into the return-to-work program, and substance abuse may be associated with avoidance or inability to access mental health treatmente
Ginexi et al.87,a Baseline: 254Follow-up 1: 228 (90)Final follow-up: 214 (84) 11 mo (3) Depression (Gender, minority status, age, SES) Reemployed job seekers showed significantly steeper linear reduction in symptoms (dropping an average of 4.55 points faster over the year).
Reemployment within 6 mo predicted declines in average and individual levels of depressive symptoms, implying that early reemployment was related to resolution of depressive symptoms
Pattern did not hold for reemployment obtained after 6 mo; job seekers who still unemployed at follow-up 1 had higher, stable level of depressive symptoms throughout study
Depressive symptoms failed to predict time to any reemployment or time to permanent full-time reemployment
Martikainen and Valkonen8,a Baseline: 2.5 millionFinal follow-up: 2.5 million (100) 5 y (3) Mortality (Age, education, occupational class, marital status) Jobless persons who were reemployed had higher mortality than those who were continuously employed, lower than those who remained unemployed, after controls for confounders
Excess mortality of unemployed persons during times of low national unemployment greater than during recession
Association between unemployment and mortality weakened as general unemployment rate increased
Mueser et al.88,a Baseline: 143Final follow-up: 133 (93) 1.5 y (4) Psychiatric symptoms (Gender, diagnosis, vocational group) Persons working at follow-up tended to have fewer symptoms (particularly thought disorder and affect on the BPRS), higher Global Assessment scores, better self-esteem, and more satisfaction with finances and vocational services than did unemployed persons. Employment was associated with better functioning in a range of nonvocational domains, even after control for baseline functioning, suggesting benefit of rehabilitation program
Results may reflect combined effects of less symptomatic patients finding jobs more easily and benefits of work for functioning, although neither hypothesis alone was directly supported by data
Payne and Jones89,a Baseline: 399Follow-up 1: 286 (71.7)Final follow-up: 144 (36.1)f 2 y (3) General psychological distress, anxiety, depression (Not reported) Perceived psychological symptoms improved, regardless of occupational status, after reemployment
Schaufeli and VanYperen90,b Baseline: 467Final follow-up: 317 (64.1) 2 y (4) Psychological distress (Gender) General tendency toward better psychological health observed in both reemployed and continuously long-term unemployed groups; long-term unemployed reached plateau health, then adapted
Less distressed long-term unemployed technical college graduates were more likely than more distressed to become reemployed, supporting selection hypothesis
Soumerai and Avorn91,a Baseline: 54Final follow-up: 47 (87%)g 6 mo (2) Perceived health status (Not reported) Strongest effect of employment program at completion was on perceived health: 8% of intervention participants reported health as fair, 36% as excellent; 45% of control participants had fair and 14% had excellent health
Results similar for perceived changes in health over the previous 6 mo
Although most respondents in both groups perceived no change health, improvements in health were far more common in intervention participants, and health declines more common in control participants; differences were statistically highly significant
Studnicka et al.92,a Baseline: 172Final follow-up: 172 (100)Unemployed–employed: 106Unemployed–unemployed: 66 1 y (2) Psychological health, physical health in past year (Age, gender, previous level of employment, physical health, previous unemployment) Persons unemployed 12 mo were 8 times as likely as the reemployed to report poor psychological health (OR = 8.5; 95% CI = 4.2, 17.0)Self-reported physical ill health likely attributable largely to former work (56% of all disorders were related by respondents to former work history) and to be associated with current employment status (OR = 5.6; 95% CI = 2.7, 11.5)
Unemployed overused health services (OR = 2.2;95% CI = 1.2, 4.1); this differential was greater for older and sicker persons
Thomas et al.93,a Baseline: 5092Final follow-up: 5092 (100) 8 y (8) Psychological distress [GHQ score ³ ≥ 3] (Age, gender, long-term sickness, previous GHQ case) For both men and women, transitions from paid employment to either unemployment or long term illness were associated with poor mental health
Transitions from unemployment into paid employment were associated with good mental health
Effects of transitions on mental health strongest in first 6 mo
People with considerable psychological distress during unemployment were less likely to become employed, supporting selection hypothesis
Vuori and Vesalainen94,a Baseline: 559Final follow-up:  401 (71.7) 1 y (2) Psychological distress [GHQ] (Baseline job seeking activity, baseline psychological distress, baseline financial situation, follow-up 1 financial situation, type of intervention) Participants who were unemployed at both measurement times reported no change in amount of distress symptoms over timeReemployed and unemployed persons at follow-up 1 did not differ in baseline distress symptoms (t(374) = 0.01; NS), failing to support selection hypothesis
At follow-up 1, reemployed persons reported significantly fewer symptoms than did unemployed (t(375) = 3.83; P < .001)
Warr and Jackson95,a Baseline: 954Follow-up 1:  629 (66) 9 mo (2) Psychological ill health [GHQ], general Health change, physical health change, psychological health change (None) Gaining (and maintaining) a job significantly improved psychological health and reported health and reduced financial strain

Note. AUDIT = Alcohol Use Disorders Identification Test; BDI = Beck Depression Inventory; BPRS = Brief Psychiatric Ratings Scale; CI = confidence interval GHQ = General Health Questionnaire; NS = not signficant; OR = odds ratio; SES = socioeconomic status.

a

Study showed a beneficial health effect of returning to work.

b

Study showed no health effect of returning to work.

c

Articles reported data from the same participants, the 1994 article83 at 2-year follow-up and the 1999 article84 at 5-year follow-up.

d

Same participants as Clausen's other articles,83,84 but reported separately because outcome and sample attrition rates were different.

e

Return-to-work group received diagnoses from mental health team; matched control participants received substance use disorder diagnoses during medical examinations, emergency room visits, and incarceration, not from study mental health team.

f

Only participants who were unemployed at baseline and follow-up 1 were reinterviewed at final follow-up.

g

For experimental group, attrition = 100%; for control group, attrition = 76%.