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. Author manuscript; available in PMC: 2012 Nov 2.
Published in final edited form as: Bioconjug Chem. 2006 Mar-Apr;17(2):317–326. doi: 10.1021/bc0502457

Figure 6.

Figure 6

Xenogen IVIS 200 imaging of Polycefin in brain glioma. Polycefin variants 20 and Polycefin(-mAb) 21 are fluorescence labeled with Alexa Fluor 680, and the valine residue (Scheme 1) is replaced by l-leucine ethyl ester. Without targeting antibody, the drug still accumulates in tumor 72 h after intravenous injection (A). Complete Polycefin with mouse targeting antibody shows significantly higher tumor retention by both amount and area (B). Imaging was carried out after flushing perfused brains with sodium-buffered saline.