Table 3. Association between the different types of virological response and the genetic variants assessed.
Genotype/allele | RVR (n = 35) | EVR (n = 73) | SVR (n = 51) | ||||
OR (95%CI) | p | OR (95%CI) | p | OR (95%CI) | p | ||
IL28B rs8099917 | TT | 1 | 1 | 1 | |||
GT | 0.41 (0.14–1.23) | 0.1 | 0.42 (0.15–1.21) | 0.25 | 0.35 (0.14–0.87) | 0.01 | |
GG | 0 | 0.44 (0.04–5.39) | 0 | ||||
T | 2.8 (1.1–7.58) | 0.03 | 1.9 (0.84–4.46) | 0.12 | 3.1 (1.41–6.79) | 0.004 | |
CTLA4 rs231775 | AA | 1 | 1 | 1 | |||
AG | 0.29 (0.09–1) | 0.03 | 0.78 (0.27–2.21) | 0.46 | 0.36 (0.08–1.72) | 0.23 | |
GG | 0.13 (0.01–1.11) | 3 (0.33–26.79) | 0.74 (0.16–3.35) | ||||
A | 3.6 (1.44–9) | 0.004 | 0.8 (0.37–1.76) | 0.6 | 1.16 (0.6–2.27) | 0.66 |
RVR: Rapid virological response. EVR: Early virological response. SVR: Sustained virological response. OR: Odds ratio. CI: confidence interval.
Odds ratio in the different genotypes are referred to the genotype with OR = 1. The value “0” means that there were no subjects carrying this genotype.
Note: the remaining genetic variants assessed showed no significant associations with RVR, EVR and SVR (p>0.05 for all comparisons).