Table 4. Association of clinical, biochemical, and therapeutic factors with SVR in patients who completed the scheduled 48-week treatment regimen with pegIFNα and ribavirin.
Variables | Odds ratio | 95% CI | p |
Male vs. female | 2.33 | 0.91–5.96 | 0.07 |
Age ≤40 vs. >40 years | 2.17 | 0.97–4.85 | 0.06 |
Weight<75 vs. ≥75 Kg | 0.48 | 0.19–1.18 | 0.1 |
CDC stage B vs. A | 0.66 | 0.2–2.17 | 0.49 |
CDC stage C vs. A | 0.42 | 0.14–1.26 | 0.12 |
HIV viral load<200 vs. ≥200 copies/mL | 1.39 | 0.55–3.5 | 0.48 |
HAART (yes vs. no) | 0.9 | 0.33–2.66 | 0.9 |
ABC (yes vs. no) | 1.46 | 0.5–4.17 | 0.48 |
HCV RNA>800000 vs. ≤800000 IU/mL | 0.9 | 0.4–2.02 | 0.8 |
HCV RNA>600000 vs. ≤600000 IU/mL | 0.69 | 0.3–1.56 | 0.37 |
HCV RNA>400000 vs. ≤400000 IU/mL | 0.54 | 0.2–1.44 | 0.22 |
HCV genotype 2+3 vs. 1+4 | 4.65 | 1.85–11.6 | 0.001 |
Fibrosis 2–4 vs. 0–1 | 1.35 | 0.56–3.3 | 0.5 |
Steatosis (yes vs. no) | 1.39 | 0.31–6.14 | 0.7 |
CD4≤350 cells/mL | 2.96 | 0.87–10 | 0.07 |
EVR (yes vs. no) | >999.999 | <0.001 | |
RVR (yes vs. no) | 31.2 | 6.56–148.37 | <0.001 |
pegIFNα 2a vs pegIFNα 2b | 1.4 | 0.65–3.17 | 0.37 |
pegIFNα: pegylated interferon alpha. CI: confidence interval. CDC: Centers for Disease Control.
HAART: highly active antiretroviral therapy. ABC: abacavir. EVR: early virological response. RVR: rapid virological response.