Table 6. Association between the different types of adverse effects and the genetic variants assessed.
| Genotypes and alleles | Gastrointestinal (n = 28) | p | Flu-like syndrome (n = 77) | p | Depression (n = 38) | p | Anemia (n = 30) | p | Neutropenia (n = 46) | p | Thrombocytopenia (n = 45) | p | |
| CTL4 rs231775 | GG | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| AG | 3.6 (0.4–32.24) | 0.48 | 2.33 (0.48–11.23) | 0.31 | 0.35 (0.08–1.48) | 0.26 | 0.17 (0.04–0.76) | 0.045 | 0.59 (0.14–2.44) | 0.76 | 0.29 (0.06–1.3) | 0.12 | |
| AA | 2.77 (0.32–24.13) | 0.79 (0.18–3.41) | 0.65 (0.17–2.52) | 0.25 (0.06–1.03) | 0.7 (0.18–2.73) | 0.23 (0.05–1.02) | |||||||
| A | 1.18 (0.56–2.5) | 0.66 | 0.68 (0.33–1.39) | 0.29 | 1.06 (0.55–2.03) | 0.87 | 0.65 (0.53–1.28) | 0.21 | 0.93 (0.49–1.76) | 0.83 | 0.55 (0.29–1.04) | 0.07 | |
| ITPA rs1127354 | CC | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| AC | 4.14 (1.25–13.72) | 0.04 | 2.7 (0.57–12.98) | 0.15 | 3.79 (1.14–12.65) | 0.06 | 0.19 (0.02–1.51) | 0.18 | 0.83 (0.25–2.7) | 0.66 | 0.87 (0.26–2.87) | 0.48 | |
| AA | 0 | 0 | 0 | 0 | 0 | 0 | |||||||
| A | 2.76 (0.95–8) | 0.054 | 1.28 (0.39–4.19) | 0.78 | 2.4 (0.85–7.06) | 0.09 | 0.17 (0.02–1.35) | 0.07 | 0.68 (0.22–2.05) | 0.49 | 1.23 (0.43–3.53) | 0.7 | |
| OAS1 rs2660 | AA | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| AG | 0.64 (0.25–1.65) | 0.18 | 0.56 (0.22–1.42) | 0.23 | 1.19 (0.49–2.88) | 0.88 | 0.35 (0.12–1) | 0.049 | 1.29 (0.55–3) | 0.81 | 1.4 (0.6–3.27) | 0.72 | |
| GG | 0.18 (0.02–1.48) | 0.37 (0.1–1.31) | 1.33 (0.37–4.71) | 1.66 (0.48–5.74) | 0.94 (0.27–3.28) | 1.02 (0.29–3.58) | |||||||
| A | 2.05 (0.98–4.32) | 0.06 | 1.77 (0.95–3.3) | 0.07 | 0.85 (0.46–1.56) | 0.59 | 1.06 (0.55–2.03) | 0.87 | 0.95 (0.52–1.72) | 0.86 | 0.89 (0.49–1.62) | 0.71 | |
| SOCS3 rs4969170 | GG | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| AG | 1.1 (0.42–2.89) | 0.97 | 1.45 (0.56–3.74) | 0.09 | 1.51 (0.62–3.64) | 0.41 | 0.67 (0.25–1.79) | 0.51 | 0.28 (0.11–0.7) | 0.02 | 0.71 (0.31–1.67) | 0.005 | |
| AA | 0.95 (0.26–3.53) | 0.4 (0.13–1.26) | 0.68 (0.19–2.47) | 1.34 (0.41–4.39) | 0.71 (0.23–2.18) | 0.06 (0.007–0.49) | |||||||
| A | 1 (0.52–1.92) | 1 | 0.69 (0.38–1.26) | 0.23 | 0.95 (0.52–1.73) | 0.86 | 1.01 (0.56–2) | 0.86 | 0.64 (0.36–1.15) | 0.13 | 0.38 (0.2–0.7) | 0.002 | |
Values are expressed as odds ratio (OR) and 95% confidence interval. Odds ratio in the different genotypes are referred to the genotype with OR = 1. The value “0” means that there were no subjects carrying this genotype.
Note: the remaining genetic variants assessed showed no significant associations with any of the adverse effects (p>0.05 for all comparisons).