Table 5.
Adjusted* yearly change in fat free mass index (FFMI) and fat mass index (FMI) for plasma CRP, TNF-α, IL-1ß and IL-6, estimated by linear mixed models with random effects
| Yearly change in FFMI | p-value | Yearly change in FMI | p-value | |
|---|---|---|---|---|
|
CRP at baseline |
|
|
|
|
| at CRP = 2.4 |
−0.0622 |
|
0.1355 |
|
| per 1 ug/mL increase |
0.0221 |
0.01 |
−0.0066 |
0.48 |
|
Sustained high CRP at year 0 and 1 |
|
|
|
|
| No |
−0.0874 |
|
0.1494 |
|
| Yes |
0.0656 |
0.01 |
0.0061 |
0.03 |
|
TNF-α at baseline |
|
|
|
|
| at TNF-α = 1.8 |
−0.0531 |
|
0.1303 |
|
| per 1 pg/mL increase |
−0.0098 |
0.13 |
0.0004 |
0.96 |
|
Sustained high TNF-α at year 0 and 1 |
|
|
|
|
| No |
−0.0643 |
|
0.1287 |
|
| Yes |
−0.2098 |
0.03 |
0.1366 |
0.91 |
|
IL-1ß at baseline |
|
|
|
|
| at IL-1ß = 0.93 |
−0.0424 |
|
0.1300 |
|
| per 1 pg/mL increase |
0.0147 |
0.16 |
0.0009 |
0.93 |
|
Sustained high IL-1ß at year 0 and 1 |
|
|
|
|
| No |
−0.0685 |
|
0.1257 |
|
| Yes |
−0.0341 |
0.58 |
0.1548 |
0.67 |
|
IL-6 at baseline |
|
|
|
|
| at IL-6 = 2.8 |
−0.0414 |
|
0.1302 |
|
| per 1 pg/mL increase |
0.0034 |
0.02 |
0.0004 |
0.79 |
|
Sustained high IL-6 at year 0 and 1 |
|
|
|
|
| No |
−0.0676 |
|
0.1291 |
|
| Yes | 0.0231 | 0.18 | 0.1184 | 0.88 |
* Adjusted for the effect of change by the interaction between yearly change and each of the baseline variables sex, age, cachexia, FEV1, smoking, hypoxemia, Charlson Index, number of exacerbations the last year, use of inhaled steroids, long acting beta2agonists, and use of theophylline.