Table 2.
Mean hormone levels
| Hormone (units) | Visit | n | Mean ± SD | Median |
|---|---|---|---|---|
| Free thyroxine (pmol/L) |
Screening |
30 |
14.42 ± 2.53 |
14.65 |
| Thyrotropin (mIU/L) |
Screening |
30 |
2.38 ± 3.30 |
1.53 |
| Estradiol (pmol/L) |
Screening |
30 |
20.54 ± 25.59 |
9.18 |
| |
6 month visit |
29 |
36.10 ± 104.95 |
9.18 |
| |
12 month visit |
26 |
25.95 ± 30.72 |
9.55 |
| LH (IU/L)* |
Screening |
30 |
0.84 ± 1.04 |
0.45 |
| |
6 month visit |
29 |
0.10 ± 0.02 |
0.10 |
| |
12 month visit |
28 |
0.11 ± 0.04 |
0.10 |
| FSH (IU/L) |
Screening |
30 |
3.86 ± 5.42 |
1.95 |
| |
6 month visit |
29 |
0.82 ± 0.78 |
0.50 |
| |
12 month visit |
29 |
1.13 ± 1.02 |
0.60 |
| Testosterone (nmol/L) |
Screening |
30 |
0.53 ± 0.19 |
0.48 |
| |
6 month visit |
29 |
0.56 ± 0.24 |
0.45 |
| 12 month visit | 28 | 0.65 ± 0.27 | 0.66 |
Prepubertal normal ranges: free thyroxine 10.3-25.7 pmol/L; thyrotropin 0.7-6.4 mIU/L; estradiol < 73.4 pmol/L; LH 0.6-1.6 IU/L; FSH 0.7-6.7 IU/L; testosterone < 0.35-1.2 nmol/L.
* P < 0.005 for median change from baseline to month 12.