FIGURE 6.

Comparison of GAT-2 and NET predicted binding sites. The final model of GAT-2 (A, white) and the model of NET (36) (B, blue) in the occluded conformation are shown with their corresponding substrates (i.e., GABA and norepinephrine, respectively) (yellow). Atoms are illustrated by sticks, with oxygen, nitrogen, and hydrogen atoms in red, blue, and white, respectively. The sodium ions Na1 and Na2 are visualized as purple spheres. GABA and norepinephrine are depicted in orange sticks, and their hydrogen bonds with GAT-2 (involving Glu-48, Gly-51, Gly-53, Asn-54, and Na1) and NET (involving Ala-145, Phe-72, and Asp-75) are shown as dotted gray lines.