TABLE 4.
Apoptotic and anti-apoptotic gene expression was analyzed by microarrays in gonads of zebrafish juveniles exposed to intermediate (I) and high (H) doses of heat-killed E. coli from 15–35 dpf compared to those of control males (CM) or control females (CF)
The q value represents the false discovery rate corrected p value derived from the linear fit to a group means paramaterization. -Fold change values between the treated groups and controls have been log2 transformed.
| Gene | CF vs. CM | q Value | I vs. CM | q value | Name |
|---|---|---|---|---|---|
| cyc1 | 5.545 | 4.22421E-13 | 5.202 | 1.14919E-12 | Cytochrome c1 |
| birc5b | 5.458 | 3.48241E-12 | 5.315 | 5.44875E-12 | Baculoviral IAP repeat-containing 5B |
| mcl1a | 2.387 | 6.10573E-11 | 2.294 | 1.19507E-10 | Myeloid cell leukemia sequence 1a |
| birc5a | 1.804 | 6.38669E-08 | 1.778 | 7.91592E-08 | Baculoviral IAP repeat-containing 5A |
| pdcd7 | 1.413 | 4.07714E-08 | 1.598 | 5.69641E-09 | Programmed cell death protein 7 homolog |
| sod1 | 1.080 | 6.32605E-05 | 1.150 | 2.98632E-05 | Superoxide dismutase |
| bcl2l13 | 0.982 | 0.244392481 | 0.323 | 0.732653483 | Bcl-2-like 13 protein |
| tradd | 0.945 | 1.72234E-06 | 1.006 | 6.88107E-07 | TNFR1-associated DEATH domain protein |
| ift57 | 0.942 | 2.5255E-06 | 0.828 | 1.45804E-05 | Intraflagellar transport protein 57 |
| timm50 | 0.938 | 0.000141313 | 0.663 | 0.003967945 | Import inner membrane translocase subunit TIM50 |
| bcl2l10 | 0.725 | 0.000281879 | 0.668 | 0.000662021 | Bcl-2-like 10 protein |
| pdcd10b | 0.722 | 2.70697E-05 | 0.824 | 4.76193E-06 | Programmed cell death protein 10B |
| dap3 | 0.651 | 0.000115272 | 0.741 | 2.46396E-05 | Death- associated protein 3 |
| aatf | 0.646 | 0.000488524 | 1.026 | 1.65076E-06 | Apoptosis-antagonizing transcription factor |
| apex1 | 0.640 | 0.002657661 | 0.905 | 8.01035E-05 | APEX nuclease |
| chek1 | 0.569 | 0.002904756 | 0.540 | 0.004424879 | Serine/threonine-protein kinase Chk1 |
| pdcd5 | 0.497 | 0.003502437 | 0.529 | 0.002112974 | Programmed cell death protein 5 |
| casp3a | 0.489 | 0.021534335 | 0.505 | 0.018007274 | Caspase 3 |
| api5 | 0.311 | 0.179674239 | 0.700 | 0.00309605 | Apoptosis inhibitor 5 |
| rybpb | 0.223 | 0.409033765 | 0.143 | 0.618438834 | Death effector domain-associated factor B |
| birc2 | 0.187 | 0.337374145 | −0.170 | 0.389206313 | Baculoviral IAP repeat-containing protein 2 |
| xrcc5 | 0.178 | 0.342167521 | 0.232 | 0.206242708 | X-ray repair cross-complementing protein 5 |
| tp53 | 0.166 | 0.547499145 | 0.267 | 0.308605818 | Tumor suppressor p53 |
| pdcd10a | −0.021 | 0.934394561 | −0.130 | 0.566305667 | Programmed cell death protein 10A |
| mrpl41 | −0.045 | 0.763067184 | −0.253 | 0.050968156 | Mitochondrial ribosomal protein L41 |
| bax | −0.076 | 0.813846548 | −0.169 | 0.581940727 | Bcl-2-associated X protein |
| bcl2l | −0.136 | 0.496224495 | −0.191 | 0.32022252 | Bcl-2-like 1 protein |
| apaf1 | −0.159 | 0.581732089 | −0.117 | 0.697171658 | Apoptotic protease-activating factor 1 |
| bad | −0.334 | 0.215793567 | −0.191 | 0.509176093 | Bcl2 antagonist of cell death |
| bcl2 | −0.418 | 0.151307689 | −0.389 | 0.183090613 | B-cell lymphoma 2 |
| dffa | −0.537 | 0.001465837 | −0.704 | 8.72749E-05 | DNA fragmentation factor subunit α |
| pdcd8 | −0.574 | 0.006444647 | −0.680 | 0.001647751 | Programmed cell death protein 8 |
| pycard | −0.637 | 0.04378308 | −0.820 | 0.010418878 | Apoptosis-associated speck-like prot. containing CARD |
| nfkbiab | −0.694 | 0.005897655 | −0.946 | 0.000374682 | NF-κB light polypeptide gene enhancer inhibitor αb |
| sgk1 | −1.002 | 0.000559778 | −0.694 | 0.011662921 | Serum/glucocorticoid-regulated kinase 1 |
| akt2l | −1.036 | 0.007551645 | −1.119 | 0.004243975 | V-akt murine thymoma viral oncogene homolog 2. like |
| rpl11 | −1.050 | 2.06218E-05 | −1.098 | 1.15201E-05 | 60 S ribosomal protein L11 |
| snai1a | −1.094 | 4.67951E-06 | −1.129 | 3.03591E-06 | Snail homolog 1a |
| ak2 | −1.246 | 7.86169E-06 | −1.452 | 9.0004E-07 | Adenylate kinase isoenzyme 2 |
| baxb | −1.343 | 1.49003E-07 | −1.381 | 9.54774E-08 | Bcl2-associated X protein, b |
| dedd1 | −1.635 | 7.21776E-08 | −1.574 | 1.29146E-07 | Death effector domain-containing 1 |
| smac | −1.695 | 0.000642094 | −1.522 | 0.001775805 | Second mitochondria-derived activator of caspase |
| tax1bp1 | −1.841 | 1.8459E-08 | −2.063 | 2.89485E-09 | Tax1-binding protein 1 |
| bnip3l | −1.941 | 4.97092E-09 | −1.902 | 7.09148E-09 | BCL2/adenovirus E1B 19 kDa-interacting protein 3-like |
| cflar | −2.585 | 5.34657E-11 | −2.610 | 4.51162E-11 | CASP8 and FADD-like apoptosis regulator precursor |
| pdcd11 | −3.346 | 6.17826E-08 | −2.841 | 7.32152E-07 | Programmed cell death protein 11 |