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Model of NIPA phosphorylation at G2/M. The initial phosphorylation at Ser-354 and Ser-359 by ERK2 dissociates and thereby inactivates the SCFNIPA complex in late G2, leading to increasing CCNB1-CDK1 kinase activity and subsequent mitotic entry. Thereafter, mitotic CCNB1-CDK1 kinase phosphorylates NIPA at Ser-395 to ensure its own activity.
