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. 2012 Sep 19;287(45):38356–38366. doi: 10.1074/jbc.M112.377382

FIGURE 1.

FIGURE 1.

Expression of growth factors and cytokines in SmoM2-expressing skin tumors. Real-time PCR was used to detect the expression of cytokines and growth factors in skin tumors and normal epidermis. Expression of several STAT3 activators were examined, including TGFα (A), IL-11 (B), IL-11Rα (C), EGF (D), KGF (E), and IL-6 (F). Fold changes in SmoM2 expressing epidermis (BCC) in comparison with normal epidermis (WT, no SmoM2 expression, as 1) was shown. *, p < 0.05. Expression of TGFα, IL-11, and IL-11Rα was further examined in keratinocytes with Gli1 knockout to determine the role of Gli transcription factors in the gene expression regulation (G shows the data on IL-11Rα).