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. 2012 Sep 19;287(45):38356–38366. doi: 10.1074/jbc.M112.377382

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Requirement of IL-11Rα for Hh signaling-induced STAT3 phosphorylation. A, expression of IL-11Rα in ES14 and C3H10T1/2 (10t) cells in presence of purmorphamine (AG). B, STAT3 phosphorylation in Hh-responsive mouse ES14 cells following treatment with Smo agonist AG. C, STAT3 phosphorylation in C3H10T1/2 cells in the presence or absence of AG. In B and C, the top panels show the Western blotting images, and the bottom panels show the analysis of the images (averaged from three independent experiments). *, p < 0.05. Note the low levels of STAT3 phosphorylation after IL-11Rα down-regulation (IL11Ra−/−).