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. Author manuscript; available in PMC: 2013 Nov 23.
Published in final edited form as: J Mol Biol. 2012 Sep 18;424(1-2):1–14. doi: 10.1016/j.jmb.2012.09.011

Figure 7.

Figure 7

Structural consequences of Ser modification in mature httNTQ37P10K2 aggregates. (a) Fraction of molecules cleaved within httNT after exposure to trypsin in various mature aggregates (WT, black bars; S13pS/S16pS, blue bars; S13D/S16D, red bars; S13pS, red hatched bar; S16pS, blue hatched bar). (b) Sedimentation assays of aggregation kinetics and plateau levels of monomer for WT (●), S13D/S16D (♦) and S13pS/S16pS (▲) peptides in PBS at 37 °C. Inset: Dissociation of S13D/S16D aggregates in PBS at 37 °C by sedimentation assay.

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