Table-4. Mean annual rates of change (ml/100g/minute) and the corresponding standard errors for resting state regional cerebral blood flow (rCBF) in TT, CT and CC groups of the rs11136000 CLU SNP.

The magnitude of change in rCBF over time was calculated within those regions showing significant associations between the number of C-alleles of rs11136000 and longitudinal changes in rCBF in the primary SPM analysis (table-3). This was performed by extracting the adjusted rCBF values at the local maxima for each region shown in table-3 using a 4-mm spherical search area. The brain regions shown above are components of the default mode network, an interacting set of brain regions involved in intrinsic memory processes.

	CC	CT	TT
Lt. Hippocampus	0.65 (0.11)	0.37 (0.09)	0.12 (0.13)
Rt. Hippocampus	0.30 (0.09)	0.10 (0.07)	−0.35 (0.16)
Rt. Anterior cingulate cortex	0.31 (0.09)	0.07 (0.08)	−0.37 (0.11)