Skip to main content
. Author manuscript; available in PMC: 2013 Sep 5.
Published in final edited form as: Cell Metab. 2012 Sep 5;16(3):348–362. doi: 10.1016/j.cmet.2012.08.003

Figure 1. Deleting PTEN in the Myf5+ lineage causes severe combined lipomatosis and partial lipodystrophy.

Figure 1

(A) Anatomy of a 6-week-old PTENmyf5cKO mutant (right) and a littermate control (left). PTENmyf5cKO mice have a horse-collar-like growth and overall torpedo shape.

(B) Lateral view of a PTENmyf5cKO mouse (bottom panel) and a control (top panel).

(C) Macroscopic images of control and PTENmyf5cKO mouse. Black arrow indicates iBAT region; white arrow indicates iWAT. White dashed circles show axillary WAT (top panels). Vertebral WAT is indicated with a black dashed circle. A star indicates the trapezius muscle.

(D) Macroscopic images of iBAT (scale bar = 5mm)

(E) Macroscopic images of rWAT (black arrow).

(F) Fat mass relative to body weight (top panel) and total fat mass (bottom panel) for the indicated tissues in 6-week-old PTENmyf5cKO mice (black bars) and controls (white bars) (n=13; Bars represent mean± SEM; T-test; ***, p<0.001).

(G) Representative images of mesenteric fat in control (left panels) and PTENmyf5cKO mouse (right panels).

(H) Representative images of perigonal WAT (black arrow). See also Figure S1.