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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: Vision Res. 2012 Jul 5;75:44–52. doi: 10.1016/j.visres.2012.06.015

Figure 4.

Figure 4

Model for IFT along C. elegans sensory cilia inferred from in vitro motility and in vivo transport assays. Upper table shows rates of MT gliding driven by purified recombinant kinesin-II, OSM-3, or mixtures of kinesin-II and OSM-3 that reconstitute the rates of transport of IFT-particles along cilia driven by kinesin-II alone (in osm-3 or bbs mutants), OSM-3 alone (in kinesin-II or bbs mutants) or kinesin-II/OSM-3 together (along wild type middle segments). Lower panel, cartoon model showing how kinesin-II and OSM-3 together move IFT particles along the cilium middle segments to build the middle segments, then OSM-3 alone moves IFT-particles along the distal segments to assemble the distal segments. See (Ou et al., 2005; Pan et al., 2006; Snow et al., 2004).