Figure 5.

B cells are necessary for the protection induced by UVΔstp1. Six-week-old wild-type (WT) C57BL/6J or B-cell–deficient muMT (µMT) mice (n = 6/group) were intravenously injected with either UVΔstp1 or phosphate-buffered saline (control). At 20 days after infection, all groups of mice were intravenously challenged with a lethal dose of Staphylococcus aureus WT Newman. Kaplan–Meier survival curve shows that both immunized and nonimmunized µMT mice succumbed to S. aureus infection (P = 1), in contrast to UVΔstp1-immunized WT mice.