Table 2.
Age- and Season-Adjusted Incidence Ratios for Acute Myocardial Infarction (AMI) Occurring After Acute Respiratory Infection (ARI) Overall and by Sex, Age, Infarction Type, and History of Vascular Disease
Model | Adjusted Incidence Ratio (95% Confidence Interval), by Period of Infection Risk in Daysa |
||||||
---|---|---|---|---|---|---|---|
1–3 (n = 52) | Pb | 4–7 (n = 44) | 8–14 (n = 48) | 15–28 (n = 80) | 29–91 (n = 262) | Baseline (n = 3441) | |
Overall | 4.19 (3.18–5.53) | 2.69 (1.99–3.63) | 1.66 (1.24–2.23) | 1.41 (1.12–1.77) | 1.05 (.92–1.21) | 1.00 | |
Sex | |||||||
Men | 4.32 (3.02–6.19) | .82 | 2.01 (1.28–3.16) | 1.28 (.83–1.97) | 1.39 (1.03–1.89) | 0.99 (.82–1.19) | 1.00 |
Women | 4.05 (2.62–6.27) | 3.66 (2.45–5.46) | 2.22 (1.50–3.29) | 1.44 (1.01–2.06) | 1.16 (.94–1.43) | 1.00 | |
Age, y | |||||||
<60 y | 1.46 (.47–4.55) | 1.46 (.54–3.91) | 1.88 (.97–3.65) | 1.50 (.88–2.56) | 0.84 (.59–1.21) | 1.00 | |
60–69 y | 3.93 (2.15–7.18) | .13c | 1.89 (.89–4.00) | 1.09 (.51–2.30) | 0.96 (.54–1.71) | 1.03 (.77–1.38) | 1.00 |
70–79 y | 4.14 (2.47–6.95) | .1c | 3.55 (2.18–5.78) | 2.31 (1.45–3.66) | 1.81 (1.23–2.65) | 0.96 (.73–1.26) | 1.00 |
≥80 y | 5.94 (3.90–9.04) | .023c | 3.18 (1.93–5.25) | 1.40 (.79–2.48) | 1.35 (.88–2.07) | 1.31 (1.04–1.66) | 1.00 |
Infarction type | |||||||
STEMI | 4.66 (3.04–7.15) | .53 | 1.76 (.97–3.21) | 1.77 (1.12–2.80) | 1.13 (.74–1.71) | 0.98 (.78–1.23) | 1.00 |
NSTEMI | 3.89 (2.71–5.60) | 3.25 (2.30–4.60) | 1.60 (1.10–2.33) | 1.58 (1.20–2.09) | 1.10 (.93–1.31) | 1.00 | |
History of vascular disease | |||||||
No | 4.32 (3.10–6.02) | .73 | 3.00 (2.12–4.25) | 1.68 (1.18–2.39) | 1.37 (1.03–1.82) | 0.99 (.83–1.17) | 1.00 |
Yes | 3.89 (2.35–6.42) | 2.03 (1.11–3.69) | 1.62 (.97–2.72) | 1.49 (1.00–2.21) | 1.19 (.95–1.51) | 1.00 |
Data are for 8204 ARIs.
Abbreviations: NSTEMI, non–ST-elevation myocardial infarction; STEMI, ST-elevation myocardial infarction.
a n values denote the no. of AMI events.
b By the Cochran Q test for heterogeneity between the 2 strata, unless otherwise indicated, during days 1–3.
c Compared with <60 y.